Product Information
Bortezomib is supplied as a lyophilized powder. For a 1 mM stock, reconstitute the 2.5 mg in 6.51 ml DMSO. Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used at 1-1000 nM for 2-48 hours. Soluble in DMSO and ethanol at 200 mg/ml, very poorly soluble in plain water.
| Molecular Weight | 384.24 g/mol |
| Purity | 99% |
| Molecular Formula | C19H25BN4O4 |
| CAS | 179324-69-7 |
| Solubility | Soluble in DMSO and EtOH at 200mg/ml. |
Bortezomib (C19H25BN4O4), a boronic acid dipeptide, is a specific, potent, and reversable proteasome inhibitor that has also been shown to have a stabilizing effect on proteins that inhibit cell survival and cell cycle progression, such as p53 (1,2). Researchers have demostrated that bortezomib inhibits activation and nuclear translocation of NF-κB, subsequently decreasing early tumor survival (3). The increase in bortezomib-stablilized, misfolded, and ubiquitinated proteins that interfere with cell survival and other important pathways further support its anti-tumor effects (3).
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| Cat. # | Size | Qty. | Price |
|---|---|---|---|
| 2204S | 2.5 mg |
|
