| Cat. # | Size | Qty. | Price |
|---|---|---|---|
| 62917S | 1 Kit |
|
| REACTIVITY | H |
| Product Includes | Quantity | Isotype | |||
|---|---|---|---|---|---|
| STING (D2P2F) Rabbit mAb (BSA and Azide Free) 67733 | 100 µg | Rabbit IgG | |||
| Phospho-STING (Ser366) (E9A9K) Rabbit mAb (BSA and Azide Free) 72650 | 100 µg | Rabbit IgG |
Product Information
Stimulator of interferon genes (STING, TMEM173, MITA) is a transmembrane adaptor protein that is a critical component of the cellular innate immune response to pathogenic cytoplasmic DNA (1,2). STING is a ubiquitously expressed protein found predominantly in the ER (1). The enzyme cGAMP synthase (cGAS) produces the second messenger cyclic-GMP-AMP (cGAMP) in response to cytoplasmic DNA (3,4). cGAMP binds and activates STING (3,4). In addition, detection of cytoplasmic DNA by nucleic acid sensors, including DDX41 or IFI16, results in STING activation (5,6). Following activation, STING translocates with TBK1 to perinuclear endosomes and gets phosphorylated by ULK1 at Ser366 (Ser365 in mouse) (7,8). The TBK1 kinase phosphorylates and activates IRF-3 and NF-κB, which leads to the induction of type I interferon and other immune response genes (1,2,7).
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