Neuroinflammation is the activation of an immune response in the CNS by the microglia and astrocytes. While not linked mechanistically to neurodegenerative diseases, neuroinflammation is associated with the progression of Alzheimer's disease, Parkinson's
Expert-reviewed interactive diagrams providing current overviews of neuronal and glial cell markers, as well as links to products from CST.
Expert-reviewed interactive neuroscience pathways providing current overviews of Parkinsons and Alzheimers Disease signaling, as well as links to products from CST.
Modulation of CNS function occurs through synaptic neurotransmission, which is the signaling from the axon terminal of one neuron to the dendrites of another via molecules called neurotransmitters.
Nuclear Permeabilization Staining: easy to follow directions describing the step by step experimental procedure.
Expert-reviewed interactive pathway providing a current overview of Nuclear Receptor Signaling, a pathway description, select PubMed references, and links to PhosphoSitePlus.
A scientific resource for the NZF protein domain containing information on structure, function, and domain binding to ubiquitin.
Optimization is critical to obtaining reliable ELISA results. The design and development of an ELISA assay depends on the various components, including capture antibody, blocking buffer, diluent, sample concentration, and detection antibody
Organelle markers for immunofluorescence analysis from CST Cell Signaling Technology
Kinome diagram showing "other" group kinases.
Learn more about our approach to science and process for creating the best antibodies in the industry
Chromatin immunoprecipitation, or ChIP, is a technique that uses antibodies to isolate specific DNA-binding proteins along with the bound DNA fragments from cells and tissues.
The chromatin immunoprecipitation (ChIP) assay is a powerful and versatile technique to probe protein-DNA interactions within the natural chromatin context of the cell.
Immunofluorescence (IF) techniques combine antibodies and fluorescence imaging to visualize biomolecules within fixed cell or tissue samples. This page answers common protocol questions to help your IF experiment be successful.
Metabolism defines all of the chemical changes or processes within cells, tissues, and organisms that sustain cellular homeostasis.
Listing of IHC-related scientific posters and papers involving scientists from Cell Signaling Technology.
Parkinson’s Disease Resource Center
A scientific resource for the PAS protein domain containing information on structure, function, and domain binding.
PathScan ELISA kits detect endogenous levels of key signaling proteins using a traditional sandwich-based assay format in phospho-specific or total protein options.
PathScan® Sandwich ELISA Antibody Pair Protocol: easy to follow directions describing the step by step experimental procedure.
Protocol for PathScan® Chemiluminescent Sandwich ELISA (for kits with Lyophilized Antibodies)
PathScan® Sandwich ELISA Protocol (Chemiluminescent): easy to follow directions describing the step by step experimental procedure.
PathScan® Sandwich ELISA Protocol (for kits with Lyophilized Antibodies) from Cell Signaling Technology with recommended companion products.
PathScan® Sandwich ELISA Protocol Colormetric: easy to follow directions describing the step by step experimental procedure.
Pathways are grouped by research area and by disease area
Find Pathways and Diagrams By Disease Area
Resources include signaling pathways, antibodies and companion products, research overviews, technical resources, and recent review articles.
A scientific resource for the PB1 protein domain containing information on structure, function, and domain binding in cytoskeletal signaling proteins.
PD-L1/PD1 immune checkpoint helps tumor cells evade detection by the immune system. Highly specific and sensitive PD-L1 antibody now available from CST.
A scientific resource for the PDZ protein domain containing information on structure, function, and domain binding.
A scientific resource for the PH domain containing information on structure, function, and domain binding to phospholipids during protein trafficking and cell signaling.
Expert scientist-authored white paper focused on phosphorylation-dependent protein interaction domains in signal transduction.
Online systems biology resource for study of post-translational modifications: phosphorylation, ubiquitination, acetylation and methylation.
The Akt Binding Partners Table provides a list of proteins that bind to Akt along with their effects, activities, and corresponding PubMed reference(s).
The PI3K / Akt Substrates Table provides a comprehensive list of demonstrated downstream targets of Akt phosphorylation.
Overview of PI3K/Akt signaling pathways, antibodies and related reagents, interactive pathway diagrams, and other technical resources.
A scientific resource for the POLO-Box protein domain containing information on structure, function, and domain binding to phospho-Ser/Thr motifs.
PTM Enrichment and Quantitation
This webinar will focus on the use of simultaneous affinity enrichment workflows by combining different PTM antibodies for ‘one-pot enrichment’ approaches
Scientific posters presented by CST scientists at various conferences and trade shows through the years.
Pre-Clinical IHC Tools for Mouse Models
The ELISA method has many variations, all of which rely on complex of an antigen and an antibody/enzyme conjugate. Signal is generated by turnover of substrate.
Privacy
The privacy policy currently in place from Cell Signaling Technology, Inc.
The privacy policy currently in place for California residents from Cell Signaling Technology, Inc.
Publications featuring Akt antibodies from Cell Signaling Technology.
Publications featuring Erk antibodies from Cell Signaling Technology.
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A table that lists shelf-life expectations for CST products (when stored under the recommended conditions).
CST product packaging is based on feedback from customers as to the number of assays they typically run.
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Alphabetical listing of protein, pathway, and antibody acronyms, curated by Cell Signaling Technology.
A categorical list of protein domain resources by Cell Signaling Technology. Each resource contains specific domain structure, function, and binding information.
A list of antibodies directed against chaperones and other proteins involved in Protein Folding offered by Cell Signaling Technology.
An introduction to human protein kinases: protein kinases are key regulators of cell function.
CST® Proteomics Analytical Services help you identify and validate drug targets, discover biomarkers, determine on/off-target effects, and mechanisms of action.
PTMScan Technology enables biomarker discovery and signaling regulation by combining enrichment of post-translational modifications with mass spectrometry.
CST sponsored Science Webinar Series: Exploring Cell Signaling through Mass Spec: May 1, 2013. Hear the webinar (3 speakers), download slides and transcripts.