Neuroinflammation is the activation of an immune response in the CNS by the microglia and astrocytes. While not linked mechanistically to neurodegenerative diseases, neuroinflammation is associated with the progression of Alzheimer's disease, Parkinson's
Expert-reviewed interactive diagrams providing current overviews of neuronal and glial cell markers, as well as links to products from CST.
Expert-reviewed interactive neuroscience pathways providing current overviews of Parkinsons and Alzheimers Disease signaling, as well as links to products from CST.
Modulation of CNS function occurs through synaptic neurotransmission, which is the signaling from the axon terminal of one neuron to the dendrites of another via molecules called neurotransmitters.
Nuclear Permeabilization Staining
(Protocols)
Nuclear Permeabilization Staining: easy to follow directions describing the step by step experimental procedure.
Nuclear Receptors
(Pathway Diagram)
Expert-reviewed interactive pathway providing a current overview of Nuclear Receptor Signaling, a pathway description, select PubMed references, and links to PhosphoSitePlus.
NZF Protein Domain
(Protein Domains)
A scientific resource for the NZF protein domain containing information on structure, function, and domain binding to ubiquitin.
Optimizing the ELISA (Enzyme-Linked Immunosorbent Assay) Test
Optimization is critical to obtaining reliable ELISA results. The design and development of an ELISA assay depends on the various components, including capture antibody, blocking buffer, diluent, sample concentration, and detection antibody
Organelle Markers
(Application Overviews)
Organelle markers for immunofluorescence analysis from CST Cell Signaling Technology
Other Protein Kinases Group
(Kinome Diagram)
Kinome diagram showing "other" group kinases.
Our Approach/Process
Learn more about our approach to science and process for creating the best antibodies in the industry
Overview of Chromatin Immunoprecipitation (ChIP)
(Application Overviews)
Chromatin immunoprecipitation, or ChIP, is a technique that uses antibodies to isolate specific DNA-binding proteins along with the bound DNA fragments from cells and tissues.
Overview of Chromatin IP Assay Methodology
(Application Overviews)
The chromatin immunoprecipitation (ChIP) assay is a powerful and versatile technique to probe protein-DNA interactions within the natural chromatin context of the cell.
Overview of Immunostaining
Immunofluorescence (IF) techniques combine antibodies and fluorescence imaging to visualize biomolecules within fixed cell or tissue samples. This page answers common protocol questions to help your IF experiment be successful.
Overview of Metabolism and Metabolic Disorders
Metabolism defines all of the chemical changes or processes within cells, tissues, and organisms that sustain cellular homeostasis.
Papers & Posters
Listing of IHC-related scientific posters and papers involving scientists from Cell Signaling Technology.
Parkinson’s Disease Resource Center
Parkinson’s Disease Resource Center
PAS Protein Domain
(Protein Domains)
A scientific resource for the PAS protein domain containing information on structure, function, and domain binding.
PathScan® ELISA (Enzyme-Linked Immunosorbent Assay) Kits
(Product Type Overviews)
PathScan ELISA kits detect endogenous levels of key signaling proteins using a traditional sandwich-based assay format in phospho-specific or total protein options.
PathScan® Sandwich ELISA Antibody Pair Protocol
(Protocols)
PathScan® Sandwich ELISA Antibody Pair Protocol: easy to follow directions describing the step by step experimental procedure.
PathScan® Sandwich ELISA Protocol (Chemiluminescent ELISA - for kits with Lyophilized Antibodies)
(Protocols)
Protocol for PathScan® Chemiluminescent Sandwich ELISA (for kits with Lyophilized Antibodies)
PathScan® Sandwich ELISA Protocol (Chemiluminescent)
(Protocols)
PathScan® Sandwich ELISA Protocol (Chemiluminescent): easy to follow directions describing the step by step experimental procedure.
PathScan® Sandwich ELISA Protocol (Colormetric ELISA - for kits with Lyophilized Antibodies)
(Protocols)
PathScan® Sandwich ELISA Protocol (for kits with Lyophilized Antibodies) from Cell Signaling Technology with recommended companion products.
PathScan® Sandwich ELISA Protocol (Colormetric ELISA)
(Protocols)
PathScan® Sandwich ELISA Protocol Colormetric: easy to follow directions describing the step by step experimental procedure.
Pathways and Diagrams
Pathways are grouped by research area and by disease area
Pathways and Diagrams by Disease Area
Find Pathways and Diagrams By Disease Area
Pathways and Diagrams by Research Area
(Pathway Diagram)
Resources include signaling pathways, antibodies and companion products, research overviews, technical resources, and recent review articles.
PB1 Protein Domain
(Protein Domains)
A scientific resource for the PB1 protein domain containing information on structure, function, and domain binding in cytoskeletal signaling proteins.
PD-L1
(Product Type Overviews)
PD-L1/PD1 immune checkpoint helps tumor cells evade detection by the immune system. Highly specific and sensitive PD-L1 antibody now available from CST.
PDZ Protein Domain
(Protein Domains)
A scientific resource for the PDZ protein domain containing information on structure, function, and domain binding.
PH Protein Domain
(Protein Domains)
A scientific resource for the PH domain containing information on structure, function, and domain binding to phospholipids during protein trafficking and cell signaling.
Phospho-dependent Protein Interaction Domains in Signal Transduction
(Protein Domains)
Expert scientist-authored white paper focused on phosphorylation-dependent protein interaction domains in signal transduction.
PhosphoSitePlus® PTM Database
Online systems biology resource for study of post-translational modifications: phosphorylation, ubiquitination, acetylation and methylation.
PI3K / Akt Binding Partners Table
(Table Resources)
The Akt Binding Partners Table provides a list of proteins that bind to Akt along with their effects, activities, and corresponding PubMed reference(s).
PI3K / Akt Substrates Table
(Table Resources)
The PI3K / Akt Substrates Table provides a comprehensive list of demonstrated downstream targets of Akt phosphorylation.
PI3K/AKT/MAPK Signaling
(Pathway Diagram)
Overview of PI3K/Akt signaling pathways, antibodies and related reagents, interactive pathway diagrams, and other technical resources.
POLO-Box Protein Domain
(Protein Domains)
A scientific resource for the POLO-Box protein domain containing information on structure, function, and domain binding to phospho-Ser/Thr motifs.
Post-translational Modification Enrichment and Quantitation for Precision Medicine and Drug Development
PTM Enrichment and Quantitation
Post-translational Modifications and Data-Independent Acquisitions - Challenges and Opportunities
This webinar will focus on the use of simultaneous affinity enrichment workflows by combining different PTM antibodies for ‘one-pot enrichment’ approaches
Poster Presentations
Scientific posters presented by CST scientists at various conferences and trade shows through the years.
Pre-Clinical IHC Tools for Mouse Models
Pre-Clinical IHC Tools for Mouse Models
Principle of ELISA (Enzyme-linked Immunosorbent Assay) Test
The ELISA method has many variations, all of which rely on complex of an antigen and an antibody/enzyme conjugate. Signal is generated by turnover of substrate.
Privacy
Privacy
Privacy Policy
The privacy policy currently in place from Cell Signaling Technology, Inc.
Privacy Statement For California Residents
The privacy policy currently in place for California residents from Cell Signaling Technology, Inc.
Product Citations for CST's Akt Antibodies
Publications featuring Akt antibodies from Cell Signaling Technology.
Product Citations for CST's Erk Antibodies
Publications featuring Erk antibodies from Cell Signaling Technology.
Product Development Request
If you have a suggestion for a new product, please fill out the form below. Our product team may contact you for more information about your needs.
Product Shelf-Life
(Product Shelflife Table)
A table that lists shelf-life expectations for CST products (when stored under the recommended conditions).
Product Sizing: Our User-Oriented Approach
(Process Explanations)
CST product packaging is based on feedback from customers as to the number of assays they typically run.
Promotions & Coupons for Cell Signaling Technology
See the latest promotions, offers and specials for Cell Signaling Technology
Protein and Pathway Abbreviations
(Table Resources)
Alphabetical listing of protein, pathway, and antibody acronyms, curated by Cell Signaling Technology.
Protein Domains & Interactions
(Protein Domains)
A categorical list of protein domain resources by Cell Signaling Technology. Each resource contains specific domain structure, function, and binding information.
Protein Folding
(Pathway Diagram)
A list of antibodies directed against chaperones and other proteins involved in Protein Folding offered by Cell Signaling Technology.
Protein Kinases
(Kinome Diagram)
An introduction to human protein kinases: protein kinases are key regulators of cell function.
Proteomics Analytical Services
(Proteomics Overviews)
CST® Proteomics Analytical Services help you identify and validate drug targets, discover biomarkers, determine on/off-target effects, and mechanisms of action.
Proteomics in Cancer Research
PTMScan Technology enables biomarker discovery and signaling regulation by combining enrichment of post-translational modifications with mass spectrometry.
Proteomics Meets Cellular Signaling: Exploring PTMs by Mass Spectrometry
CST sponsored Science Webinar Series: Exploring Cell Signaling through Mass Spec: May 1, 2013. Hear the webinar (3 speakers), download slides and transcripts.
NF-κB Signaling
(Pathway Diagram)