Enumerates known oncogenes and tumor suppressors, with corresponding genetic alterations and cellular effects.
Protein | Genetic Alterations | Evading Apoptosis | Self-Suffciency in Growth Status | Insensitivity to Anti-Growth Signals | Tissue Invasion & Metastasis | Sustained Angiogenesis | |
---|---|---|---|---|---|---|---|
![]() | Akt | Point mutation, amplification, increased expression | ![]() | ||||
![]() | Bax | Point mutation | ![]() | ||||
![]() | FKHR/FoxO | Translocation | ![]() | ||||
![]() | PI3K | Point mutation | ![]() | ||||
![]() | Bcl2 | Translocation | ![]() | ||||
![]() | INPP4B | Deletion, loss of heterozygosity, reduced expression | |||||
![]() | LKB1 | Point mutation | ![]() | ![]() | |||
![]() | PTEN | Point mutation, deletion | ![]() | ||||
![]() | TSC1/TSC2 | Point mutation | ![]() |
Table Key: Oncogenes
Tumor Suppressors
Indicates Protein Function
Protein | Genetic Alterations | Evading Apoptosis | Self-Suffciency in Growth Status | Insensitivity to Anti-Growth Signals | Tissue Invasion & Metastasis | Sustained Angiogenesis | |
---|---|---|---|---|---|---|---|
![]() | Abl | Translocation | ![]() | ||||
![]() | Cdk-2 | Amplification, increased expression | ![]() | ||||
![]() | Cdk-4 | Point mutation | ![]() | ||||
![]() | Cyclin D | Amplification, translocation | ![]() | ||||
![]() | Cyclin E | Amplification | ![]() | ||||
![]() | HPV-E7 | Viral Infection | ![]() | ||||
![]() | p15 | Point mutation | ![]() | ||||
![]() | p16 | Point mutation | ![]() | ||||
![]() | p57 | Point mutation | ![]() | ||||
![]() | Rb | Point mutation | ![]() |
Table Key: Oncogenes
Tumor Suppressors
Indicates Protein Function
Protein | Genetic Alterations | Evading Apoptosis | Self-Suffciency in Growth Status | Insensitivity to Anti-Growth Signals | Tissue Invasion & Metastasis | Sustained Angiogenesis | |
---|---|---|---|---|---|---|---|
![]() | Aurora A | Amplification, increased expression | ![]() | ||||
![]() | HPV-E6 | Viral Infection | ![]() | ||||
![]() | Mdm2 | Amplification | ![]() | ||||
![]() | ARF | Point mutation | ![]() | ||||
![]() | ATM/ATR | Point mutation | ![]() | ||||
![]() | BRCA1 | Point mutation | ![]() | ![]() | |||
![]() | Chk1 | Point mutation | ![]() | ||||
![]() | Chk2 | Point mutation | ![]() | ||||
![]() | DNA-PK | Point mutation | ![]() | ||||
![]() | FANCs | Point mutation | ![]() | ||||
![]() | HIPK2 | Point mutation | ![]() | ![]() | |||
![]() | NBS1 | Point mutation, deletion | ![]() | ||||
![]() | p53 | Point mutation, deletion | ![]() | ![]() | |||
![]() | WT1 | Point mutation, deletion | |||||
![]() | MUTYH | Point mutation, deletion | |||||
![]() | BLM | Point mutation, deletion | |||||
![]() | RECQL4 | Point mutation, deletion | |||||
![]() | WRN | Deletion, insertion | |||||
![]() | MMR genes | Point mutation, reduced expression | |||||
![]() | XPA, C, D | Point mutation | |||||
![]() | FBXW7 | Point mutation |
Table Key: Oncogenes
Tumor Suppressors
Indicates Protein Function
Protein | Genetic Alterations | Evading Apoptosis | Self-Suffciency in Growth Status | Insensitivity to Anti-Growth Signals | Tissue Invasion & Metastasis | Sustained Angiogenesis | |
---|---|---|---|---|---|---|---|
![]() | Fas | Point mutation | ![]() |
Table Key: Oncogenes
Tumor Suppressors
Indicates Protein Function
Protein | Genetic Alterations | Evading Apoptosis | Self-Suffciency in Growth Status | Insensitivity to Anti-Growth Signals | Tissue Invasion & Metastasis | Sustained Angiogenesis | |
---|---|---|---|---|---|---|---|
![]() | Ga | Point mutation | ![]() | ||||
![]() | GPCR | Point mutation | ![]() |
Table Key: Oncogenes
Tumor Suppressors
Indicates Protein Function
Protein | Genetic Alterations | Evading Apoptosis | Self-Suffciency in Growth Status | Insensitivity to Anti-Growth Signals | Tissue Invasion & Metastasis | Sustained Angiogenesis | |
---|---|---|---|---|---|---|---|
![]() | Gli | Amplification, translocation | ![]() | ![]() | |||
![]() | Hedgehog | Point mutation | ![]() | ![]() | |||
![]() | Smo | Point mutation | ![]() | ![]() | |||
![]() | Ptch | Point mutation | ![]() | ![]() | |||
![]() | Su(Fu) | Point mutation | ![]() | ![]() | |||
![]() | EXT1,2 | Point mutation, deletion, insertion | ![]() | ![]() |
Table Key: Oncogenes
Tumor Suppressors
Indicates Protein Function
Protein | Genetic Alterations | Evading Apoptosis | Self-Suffciency in Growth Status | Insensitivity to Anti-Growth Signals | Tissue Invasion & Metastasis | Sustained Angiogenesis | |
---|---|---|---|---|---|---|---|
![]() | Notch | Translocation | ![]() |
Table Key: Oncogenes
Tumor Suppressors
Indicates Protein Function
Protein | Genetic Alterations | Evading Apoptosis | Self-Suffciency in Growth Status | Insensitivity to Anti-Growth Signals | Tissue Invasion & Metastasis | Sustained Angiogenesis | |
---|---|---|---|---|---|---|---|
![]() | B-Raf | Point mutation, amplification, increased expression | ![]() | ||||
![]() | Fos/Jun | Increased expression | ![]() | ![]() | |||
![]() | ILK | Increased expression | ![]() | ![]() | |||
![]() | Ras | Point mutation | ![]() | ||||
![]() | RTKs | Point mutation, translocation, amplification, increased expression | ![]() | ![]() | ![]() | ![]() | |
![]() | Integrin | Deletion | ![]() | ||||
![]() | NF1 | Point mutation, deletion | ![]() | ||||
![]() | NF2 | Point mutation, deletion | ![]() | ![]() | |||
![]() | VHL | Point mutation | ![]() | ||||
![]() | FH | Point mutation | |||||
![]() | SDH | Point mutation, deletion |
Table Key: Oncogenes
Tumor Suppressors
Indicates Protein Function
Protein | Genetic Alterations | Evading Apoptosis | Self-Suffciency in Growth Status | Insensitivity to Anti-Growth Signals | Tissue Invasion & Metastasis | Sustained Angiogenesis | |
---|---|---|---|---|---|---|---|
![]() | Myc | Point mutation, amplification | ![]() | ||||
![]() | BMPR | Point mutation | ![]() | ||||
![]() | Smad2/3 | Point mutation | ![]() | ||||
![]() | Smad4 | Point mutation | ![]() | ||||
![]() | TGFβR | Point mutation | ![]() | ||||
![]() | MEN1 | Point mutation | ![]() |
Table Key: Oncogenes
Tumor Suppressors
Indicates Protein Function
Protein | Genetic Alterations | Evading Apoptosis | Self-Suffciency in Growth Status | Insensitivity to Anti-Growth Signals | Tissue Invasion & Metastasis | Sustained Angiogenesis | |
---|---|---|---|---|---|---|---|
![]() | β-catenin | Point mutation | ![]() | ||||
![]() | RAR | Amplification | ![]() | ||||
![]() | SOX | Amplification, increased expression | ![]() | ||||
![]() | Wnt1 | Increased expression | ![]() | ||||
![]() | APC | Point mutation | ![]() | ||||
![]() | Axin | Point mutation | ![]() | ||||
![]() | α-catenin | Point mutation | ![]() | ||||
![]() | E-cadherin | Point mutation | ![]() | ![]() | ![]() | ||
![]() | Wnt5A | Point mutation | ![]() | ||||
![]() | GPC3 | Deletions, point mutation | ![]() | ||||
![]() | HRPT2 | Point mutation | ![]() |
Table Key: Oncogenes
Tumor Suppressors
Indicates Protein Function
Protein | Genetic Alterations | Evading Apoptosis | Self-Suffciency in Growth Status | Insensitivity to Anti-Growth Signals | Tissue Invasion & Metastasis | Sustained Angiogenesis | |
---|---|---|---|---|---|---|---|
![]() | TAL1 | Translocation | ![]() | ||||
![]() | MLL | Translocation | ![]() | ||||
![]() | HOXs | Translocation, point mutation | ![]() | ||||
![]() | MITF | Amplification | ![]() | ![]() | |||
![]() | EVI1 | Translocation | ![]() | ||||
![]() | BCL6 | Translocation, point mutation | |||||
![]() | HPC1 | Point mutation |
Table Key: Oncogenes
Tumor Suppressors
Indicates Protein Function