Product Information
| Molecular Weight | 540.73 g/mol |
| Purity | >98% |
| Molecular Formula | C33H48O6 |
| CAS | 87081-35-4 |
| Solubility | Soluble and stable in ethanol. Leptomycin B is not stable in DMSO; do not dilute in DMSO. |
Leptomycin B (LMB), originally discovered and utilized as a potent anti-fungal antibiotic from Streptomyces sp., has more recently been identified to inhibit nuclear export of proteins and RNA containing a Nuclear Export Sequence (NES) (1). The mechanism behind LMB's potent inhibition is achieved by specifically binding to chromosomal region maintenance (CRM)/exportin 1 protein; CRM1 binds to ribonuclear proteins containing the NES (1,2). LMB has also been reported to inhibit the degradation and subsequently lead to accumulation of p53 within the nucleus (3) and has demonstrated specific anti-tumor properties, although toxic, at high doses (1-3).
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| Cat. # | Size | Qty. | Price |
|---|---|---|---|
| 9676S | 50 µg |
|
