Product Information
Oligomycin is supplied as a lyophilized powder. For a 5 mM stock, reconstitute the 5 mg in 1.26 ml DMSO. Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used at 0.5 - 10 μM for 0.5 - 8 hours.
| Molecular Weight | 791.1 g/mol |
| Purity | 97% |
| Molecular Formula | Isomer A: C45H74O11 Isomer B: C45H72O12 Isomer C: C45H74O10 |
| CAS | 1404-19-9 |
| Solubility | Soluble in DMSO at 300mg/ml and EtOH at 200mg/ml. |
During oxidative phosphorylation in mitochondria, the electron transport system pumps H+ from the matrix into the intermembrane compartment. This process generates a H+ gradient across the mitochondrial inner membrane. This H+ gradient is used to drive mitochondrial FoF1 ATPase to convert ADP to ATP. Oligomycin, an antibiotic from Streptomyces diastatochromogenes, blocks oxidative phosphorylation by binding to the Fo part of the ATPase to inhibit its activity (1-3).
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| Cat. # | Size | Qty. | Price |
|---|---|---|---|
| 9996L | 5 mg |
|
