Product Information
Aphidicolin is supplied as a lyophilized powder. For a 5 mM stock, reconstitute 1 mg of powder in 590 μl of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
| Molecular Weight | 338.5 g/mol |
| Purity | >98% |
| Molecular Formula | C20H34O4 |
| CAS | 38966-21-1 |
| Solubility | Soluble in DMSO at 10 mg/ml or ethanol at 1 mg/ml. |
Aphidicolin is a tetracyclic diterpenoid first produced by the fungus Cephalosporium aphidicola. This antibiotic is a potent inhibitor of cellular deoxyribonucleic acid (DNA) synthesis by targeting α, ε, and δ DNA polymerases in eukaryotic cells lines with little to no effect on β or γ DNA polymerases (1,2). Studies have shown that Aphidicolin specifically binds to α DNA polymerase, resulting in the formation of a pol α-DNA-aphidicolin ternary complex that blocks DNA replication. The uses for this compound include synchronized cells at the G1/S boundary and increased gene amplification (3-6).
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| Cat. # | Size | Qty. | Price |
|---|---|---|---|
| 32774S | 1 mg |
|
