Product Information
(+)-JQ1 is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.09 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
| Molecular Weight | 457 g/mol |
| Purity | >98% |
| Molecular Formula | C23H25ClN4O2S |
| CAS | 1268524-70-4 |
| Solubility | Soluble in DMSO at 60 mg/ml or ethanol at 46 mg/ml. |
(+)-JQ1 is a potent BET bromodomain inhibitor with IC50 values of 77 nM and 33 nM for BRD4 bromodomain 1 and BRD4 bromodomain 2, respectively. This small molecule competitively binds to the acetyl-lysine recognition pocket of BET bromodomains, which in turn displaces BET proteins from chromatin (1). The BET family of proteins are associated in many different cellular processes, including mitosis, viral/host interaction, and inflammatory gene expression (2-4). Studies have shown that (+)-JQ1 induced autophagy through LKB1/AMPK pathway activation can inhibit bladder cancer (BC) cell proliferation (5).
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| Cat. # | Size | Qty. | Price |
|---|---|---|---|
| 84566S | 5 mg |
|
