Product Information
MDL-28170 (Calpain Inhibitor III) is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.30 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
| Molecular Weight | 382.5 g/mol |
| Purity | >98% |
| Molecular Formula | C22H26N2O4 |
| CAS | 88191-84-8 |
| Solubility | Soluble in DMSO at 75 mg/ml. |
MDL-28170 (Calpain Inhibitor III) is a potent and selective inhibitor of Calpain-1 (mu-type) and Calpain-2 (M-type) (1). This cell-permeable small molecule has been shown to cross the blood-brain barrier and has demonstrated neuroprotective effects in several rodent models making it a useful tool for studying neurodegenerative disease and neurotrauma as well as ischemic reperfusion (2,3). MDL-28170 (Calpain Inhibitor III) has an EC50 value of 14 μM when tested in a cell-based assay and has shown to be an effective antiviral agent, inhibiting SARS-CoV replication in Vero 76 cells with an IC50 value of 10 μM (4,5).
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| Cat. # | Size | Qty. | Price |
|---|---|---|---|
| 10727S | 5 mg |
|
