Product Information
Paclitaxel is supplied as 1 mg powder. Store at or below -20ºC. Before use, dissolve powder in 1.15 ml DMSO to make a 1 mM paclitaxel stock solution. For working concentrations of 100 nM-1000 nM, dilute DMSO stock 1:10,000 to 1:1000. Treat cells with the desired concentration for 6-48 hours.
| Molecular Weight | 853.9 g/mol |
| Purity | >99.5% |
| Molecular Formula | C47H51NO14 |
| CAS | 33069-62-6 |
| Solubility | Soluble in DMSO at 25mg/ml or EtOH at 20mg/ml. |
Paclitaxel belongs to the taxane family of antitumor and antileukemic agents (3). By binding to β-tubulin and promoting the assembly of microtubules, paclitaxel prevents microtubual depolymerization and blocks normal cell division (1-3). The microtubule dysfunction induced by paclitaxel results in aberrant cell mitosis and sometimes apoptosis. The IC50 of paclitaxel-induced mitotic block is 4 nM (4).
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| Cat. # | Size | Qty. | Price |
|---|---|---|---|
| 9807S | 1 mg |
|
