Product Information
TPA is supplied as a 1 mg powder. Store at -20C. Before use, dissolve powder in 1 ml DMSO to yield a 1.6 mM stock solution. For working concentration of 200 μM, add 125 μl stock solution to 875 μl DMSO. Treat cells with 200 nM TPA for 20-30 minutes.
TPA is soluble in DMSO and ethanol.
| Molecular Weight | 616.83 g/mol |
| Purity | >99.5% |
| Molecular Formula | C36H56O8 |
| CAS | 16561-29-8 |
| Solubility | Soluble in DMSO and EtOH at 25mg/ml. |
TPA (12-O-tetradecanoylphorbol-13-acetate) / PMA (phorbol-12-myristate-13-acetate) is the most commonly used phorbol ester. It binds and activates protein kinase C, causing a wide range of effects in cells and tissues (1,2). TPA has been demonstrated to be a potent tumor promoter in mouse skin (3). Conversely, it has been shown to be an effective cancer therapeutic agent in myelocytic leukemia patients, and has been indicated as a potential colorectal cancer therapeutic (4-5). TPA has also been shown to increase white blood cell and neutrophil counts in solid tumor cancer patients (6).
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| Cat. # | Size | Qty. | Price |
|---|---|---|---|
| 4174S | 1 mg |
|
