Product Information
U-18666A is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.17 ml of water. Working concentrations and length of treatment can vary depending on the desired effect.
| Molecular Weight | 424.1 g/mol |
| Purity | >98% |
| Molecular Formula | C25H41NO2 • HCl |
| CAS | 3039-71-2 |
| Solubility | Soluble in water at 20 mg/ml. |
U-18666A is a cell permeable drug that inhibits cholesterol transport. This small molecule inhibits low density lipoprotein (LDL)-derived cholesterol transport, blocking cholesterol esterification, and suppressing LDL receptor activities (1). Studies have shown that impaired cholesterol trafficking is associated with neurological diseases such as Alzheimer’s disease (AD), Niemann-Pick disease type C (NPC), and atherosclerosis (2,3). The mechanisms of neurodegeneration for these diseases are mostly unknown so studies using U-18666A to simulate intracellular cholesterol accumulation may provide greater insight into these pathologies (2). Cholesterol levels play a role in the body’s response to viral infection and the ability of a virus to enter and replicate within a host cell, making U-18666A an important compound when studying different viral diseases (4).
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| Cat. # | Size | Qty. | Price |
|---|---|---|---|
| 68998S | 5 mg |
|
