Product Information
Working concentration of recombinant hIL-21 generally ranges from 0.1-10 ng/ml.
| MW (kDa) | 16 |
| Purity | A greater than 95% purity was determined by SDS-PAGE. |
| Endotoxin | Less than or equal to 1 EU / 1 μg hIL-21. |
| Activity | The bioactivity of recombinant hIL-21 was determined by its ability to induce IFN-γ production in B9 cells. The ED50 of each lot is between 25-50 ng/ml. |
Recombinant human IL-21 was expressed in E. coli and is supplied in a lyophilized form.
IL-21 is produced by Th17, T follicular helper (Tfh) and NKT cells (1-3). Targets include T cells, B cells, NK cells and dendritic cells (1-3,5). IL-21 induces proliferation and activation of NK cells, thereby up-regulating IFN-γ production and cytotoxic activity (1,3,4). IL-21 increases proliferation and survival of CD40-primed B cells (1,2) and appears to have a significant role in plasma cell differentiation (2). IL-21 binds to a complex consisting of IL-21Rα and the common γ chain, γc. IL-21 binding activates the Jak1/Jak3, Stat1, Stat3 and Stat5 pathway. IL-21 binding can also activate the MAP kinase and PI3K/Akt pathways.
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| Cat. # | Size | Qty. | Price |
|---|---|---|---|
| 45095S | 10 µg |
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