Overview of cell cycle and DNA damage signaling networks, antibodies and related reagents, interactive pathway diagrams, and technical resources.
Control Treatments by Target
(Control Table)
A list of recommended cell types and treatments to be used as positive and negative controls for activation state specific antibodies
Find alternatives to Santa Cruz antibodies
Use the lookup tool to find the CST equivalent for your SCBT product.
Kinase-Disease Associations
(Table Resources)
Kinase-disease associations table showing kinases, kinase groups, disease types, and the molecular biology basis for disease.
Ubiquitin Ligase Table
(Table Resources)
The Ubiquitin Ligase Table provides a comprehensive list of E3 ubiquitin ligases along with their substrates and corresponding PubMed reference(s).
Cellular Senescence
Cellular senescence is stable cell cycle arrest linked to aging and cancer and other disease states, including those associated with inflammation. It is induced by DNA damage, oncogenic signaling, and telomere shortening.
PI3K / Akt Substrates Table
(Table Resources)
The PI3K / Akt Substrates Table provides a comprehensive list of demonstrated downstream targets of Akt phosphorylation.
Human Oncogenes & Tumor Suppressor Genes
(Table Resources)
Summary of human oncogenes and tumor suppressor genes sorted by signaling pathway.
G1/S Checkpoint
(Pathway Diagram)
Regulation of Apoptosis
(Pathway Diagram)