Overview of cell cycle and DNA damage signaling networks, antibodies and related reagents, interactive pathway diagrams, and technical resources.
Ubiquitin Ligase Table
(Table Resources)
The Ubiquitin Ligase Table provides a comprehensive list of E3 ubiquitin ligases along with their substrates and corresponding PubMed reference(s).
PI3K / Akt Substrates Table
(Table Resources)
The PI3K / Akt Substrates Table provides a comprehensive list of demonstrated downstream targets of Akt phosphorylation.
PI3K / Akt Binding Partners Table
(Table Resources)
The Akt Binding Partners Table provides a list of proteins that bind to Akt along with their effects, activities, and corresponding PubMed reference(s).
Control Treatments by Target
(Control Table)
A list of recommended cell types and treatments to be used as positive and negative controls for activation state specific antibodies
Protein and Pathway Abbreviations
(Table Resources)
Alphabetical listing of protein, pathway, and antibody acronyms, curated by Cell Signaling Technology.
Human Oncogenes & Tumor Suppressor Genes
(Table Resources)
Summary of human oncogenes and tumor suppressor genes sorted by signaling pathway.
RING Protein Domain
(Protein Domains)
A scientific resource for the RING protein domain containing information on structure, function, and domain binding to ubiquitin in protein degradation pathways.
Examples of Crosstalk Between Post-translational Modifications
(Pathway Diagram)