Cat. # | Size | Qty. | Price |
---|---|---|---|
40415T | 1 Kit (9 x 20 microliters) |
|
Product Includes | Quantity | Applications | Reactivity | MW(kDa) | Isotype |
---|---|---|---|---|---|
TBK1/NAK (E8I3G) Rabbit mAb 38066 | 20 µl |
|
H M R | 84 | Rabbit IgG |
MAVS (D5A9E) Rabbit mAb 24930 | 20 µl |
|
H | 75, 52 | Rabbit IgG |
TRAF2 (C192) Antibody 4724 | 20 µl |
|
H M Mk | 53 | Rabbit |
TRAF3 (E8H3B) Rabbit mAb 33640 | 20 µl |
|
H M R | 62 | Rabbit IgG |
TRAF6 (E2K9D) Rabbit mAb 67591 | 20 µl |
|
H M R | 60 | Rabbit IgG |
Phospho-TBK1/NAK (Ser172) (D52C2) XP® Rabbit mAb 5483 | 20 µl |
|
H M | 84 | Rabbit IgG |
IRF-3 (D6I4C) XP® Rabbit mAb 11904 | 20 µl |
|
H Mk | 50-55 | Rabbit IgG |
Phospho-IRF-3 (Ser386) (E7J8G) XP® Rabbit mAb 37829 | 20 µl |
|
H | 50-55 | Rabbit IgG |
Phospho-IRF-3 (Ser396) (D6O1M) Rabbit mAb 29047 | 20 µl |
|
H M R | 45-55 | Rabbit IgG |
Anti-rabbit IgG, HRP-linked Antibody 7074 | 100 µl |
|
Goat |
Product Information
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Cys192 of human TRAF2. Antibodies are purified by protein A and peptide affinity chromatography. Monoclonal antibodies are produced by immunizing animals with recombinant human IRF-3 protein and recombinant protein specific to a central region of mouse TRAF6, or synthetic phosphopeptides corresponding to residues surrounding Ser172 of human TBK1, Ser386 of human IRF-3, and Ser396 of human IRF-3 protein, or synthetic peptides corresponding to residues surrounding Leu202 of human MAVS and Ala327 of human TRAF3, or near the carboxy terminus of human TBK1/NAK protein.
Recognition of conserved molecular structures of viruses by host pattern-recognition receptors (PRRs) initiates innate antiviral immune responses. Several families of PRRs have been demonstrated to sense different microbial components (1,2). The RIG-I-like receptor (RLR) family, including RIG-I, MDA5, and LGP2, are the primary PRRs to recognize viral RNAs (3,4). Upon binding to viral RNA, these receptors undergo conformation change, leading to their interaction with mitochondrial antiviral signaling protein (MAVS). MAVS subsequently forms large prion-like polymers and serves as a platform to recruit multiple components, including TRAF proteins and TBK1, to form the so-called MAVS signalosome. MAVS signalosome, in turn, activates the IRF-3 and NF-kB pathways, leading to the production of type I IFNs and pro-inflammatory cytokines (5-9).
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