| Cat. # | Size | Qty. | Price |
|---|---|---|---|
| 30590T | 1 Kit (4 x 20 microliters) |
|
| Product Includes | Quantity | Applications | Reactivity | MW(kDa) | Isotype |
|---|---|---|---|---|---|
| PTEN (D4.3) XP® Rabbit mAb 9188 | 20 µl |
|
H M R Mk Dg | 54 | Rabbit IgG |
| Phospho-PTEN (Ser380/Thr382/383) (44A7) Rabbit mAb 9549 | 20 µl |
|
H M R Mk | 54 | Rabbit IgG |
| PDK1 (D37A7) Rabbit mAb 5662 | 20 µl |
|
H M R Hm Mk | 58-68 | Rabbit IgG |
| Phospho-PDK1 (Ser241) (C49H2) Rabbit mAb 3438 | 20 µl |
|
H M R | 58 to 68 | Rabbit IgG |
| Anti-rabbit IgG, HRP-linked Antibody 7074 | 100 µl |
|
Goat |
Product Information
PTEN (D4.3) XP® Rabbit mAb is produced by immunizing animals with a synthetic peptide corresponding to residues in the carboxy-terminal sequence of human PTEN. Phospho-PTEN (Ser380/Thr382/383) (44A7) Rabbit mAb is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues around Ser380, Thr382 and Thr383 of human PTEN. PDK1 (D37A7) Rabbit mAb is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human PDK1 protein. Phospho-PDK1 (Ser241) (C49H2) Rabbit mAb is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues around Ser241 of human PDK1.
PTEN (phosphatase and tensin homologue deleted on chromosome ten), also referred to as MMAC (mutated in multiple advanced cancers) phosphatase, is a tumor suppressor implicated in a wide variety of human cancers (1). PTEN encodes a 403 amino acid polypeptide originally described as a dual-specificity protein phosphatase (2). The main substrates of PTEN are inositol phospholipids generated by the activation of the phosphoinositide 3-kinase (PI3K) (3). PTEN is a major negative regulator of the PI3K/Akt signaling pathway (1,4,5). PTEN possesses a carboxy-terminal, noncatalytic regulatory domain with three phosphorylation sites (Ser380, Thr382, and Thr383) that regulate PTEN stability and may affect its biological activity (6,7). PTEN regulates p53 protein levels and activity (8) and is involved in G protein-coupled signaling during chemotaxis (9,10).
Phosphoinositide-dependent protein kinase 1 (PDK1) plays a central role in many signal transduction pathways (11,12), including the activation of Akt and the PKC isoenzymes p70 S6 kinase and RSK (13). Through its effects on these kinases, PDK1 is involved in the regulation of a wide variety of processes, including cell proliferation, differentiation, and apoptosis.
Explore pathways related to this product.
STRING - Known and Predicted Protein-Protein Interactions.
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