Cat. # | Size | Qty. | Price |
---|---|---|---|
43573T | 1 Kit (9 x 20 microliters) |
|
Product Includes | Quantity | Applications | Reactivity | MW(kDa) | Isotype |
---|---|---|---|---|---|
Phospho-IRF-3 (Ser386) (E7J8G) XP® Rabbit mAb 37829 | 20 µl |
|
H | 50-55 | Rabbit IgG |
IRF-3 (D6I4C) XP® Rabbit mAb 11904 | 20 µl |
|
H Mk | 50-55 | Rabbit IgG |
Phospho-IRF-7 (Ser477) (D7E1W) Rabbit mAb 12390 | 20 µl |
|
H | 65 | Rabbit IgG |
IRF-7 (D2A1J) Rabbit mAb 13014 | 20 µl |
|
H | 65 | Rabbit IgG |
IFN-β1 (D1D7G) Rabbit mAb 73671 | 20 µl |
|
H | 19, 21 | Rabbit IgG |
Phospho-Stat1 (Ser727) (D3B7) Rabbit mAb 8826 | 20 µl |
|
H M R Mk | 91 | Rabbit IgG |
Stat1 (D1K9Y) Rabbit mAb 14994 | 20 µl |
|
H M R Mk | 84, 91 | Rabbit IgG |
IRF-9 (D2T8M) Rabbit mAb 76684 | 20 µl |
|
H | 48 | Rabbit IgG |
MX1 (D3W7I) Rabbit mAb 37849 | 20 µl |
|
H | 76 | Rabbit IgG |
Anti-rabbit IgG, HRP-linked Antibody 7074 | 100 µl |
|
Goat |
Product Information
Monoclonal antibodies are produced by immunizing rabbits with synthetic peptides corresponding to residues surrounding Pro115 of human IRF-7, Pro688 of human Stat1, Leu292 of human MX1, recombinant human IRF-3 protein, recombinant human IFN-β1 protein, and recombinant human IRF-9 protein. Phosphorylation-specific monoclonal antibodies are produced by immunizing rabbits with synthetic peptides corresponding to residues surrounding Ser386 of human IRF-3, Ser477 of human IRF-7, and Ser727 of human Stat1.
The innate immune system uses pattern recognition receptors (PRRs) that detect conserved pathogen-associated molecular patterns (PAMPs), such as cytoplasmic double-stranded RNA, to detect and initiate an immune response to viral infection. Detection of virus by PRRs leads to phosphorylation and nuclear translocation of IRF-3 and IRF-7, resulting in upregulation of type I interferons, which include IFN-α and IFN-β (1-3). Type I interferons signal through the interferon α/β receptor (IFNAR), leading to phosphorylation and activation of Stat1 and Stat2, which form a complex with IRF-9 (4,5). This complex translocates to the nucleus where it induces transcription of interferon response genes including viral restriction factors, such as MX1, that limit viral replication and propagation (4-7).
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